Effexor - antidepressant. Active ingredient - venlafaxine and its main metabolite O-desmetilvenlafaxine which are strong inhibitors of the return serotonin reuptake and noradrenaline and weak inhibitors of the return capture of a dopamine. It is considered that the mechanism of antidepressive action is connected with ability of drug to strengthen transfer of nervous impulses in CNS.

A tricyclic antidepressant with a relatively short latency period. It has almost no sedative effect. therapeutical indications include: depressive phases of a manic-depressive psychosis, all other forms of endogenous depression (reactive and neurotic). In combination with amitriptyline it is used for depressions that occurred during treatment with reserpine. In combination with neuroleptics, it is used in the treatment of depression that developed during treatment of schizophrenic psychoses.

Pamelor is a tricyclic antidepressant (TCA, tricyclic antidepressants) of the second generation. It is used in the treatment of some major depressive disorder and nocturnal enuresis (bedwetting) in children. In addition, the drug is sometimes used for the treatment of chronic diseases such as chronic fatigue syndrome, chronic pain and migraine, and the lability in certain neurological diseases.